A concise approach towards the synthesis of WS75624 A and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles

作者：Dash Jyotirmayee; Melillo Bruno; Arseniyadis Stellios^*; Cossy Janine

来源：Tetrahedron Letters, 2011, 52(17): 2246-2249.

DOI：10.1016/j.tetlet.2011.01.027

• Cross-metathesis
• Natural products
• Alkene
• Thiazole
• Pyridine

Synthetic approach towards precursors of WS75624 A and WS75624 B, two potent endothelin converting enzyme (ECE) inhibitors and potential antihypertensive agents, is reported featuring a key cross-metathesis between a vinyl-functionalized thiazole and a terminal olefin. As the two natural products only differ by the nature of their hydroxyalkyl side-chain, our convergent strategy enable the synthesis of key intermediates of both molecules in a limited amount of steps.

• 出版日期2011-4-27