Procalcitonin as a prognostic marker in patients with acute myocardial infarction

作者：Kelly Dominic^*; Khan Sohail Q; Dhillon Onkar; Quinn Paulene; Struck Joachim; Squire Iain B; Davies Joan E; Ng Leong L

来源：Biomarkers, 2010, 15(4): 325-331.

DOI：10.3109/13547501003675084

• Myocardial infarction
• heart failure
• biomarkers
• procalcitonin

Background: Procalcitonin is involved in the inflammatory response and is associated with adverse prognosis in certain conditions.
Aims: To investigate the association between procalcitonin and major adverse cardiac events (MACE), left ventricular (LV) function and remodelling following acute myocardial infarction (AMI).
Methods: Plasma procalcitonin was measured in 977 patients with AMI. Subjects were followed for MACE (median 671 days). A subgroup underwent echocardiography at discharge and follow-up LV function and volume assessment.
Results: Procalcitonin was associated with MACE on uni- and multivariable analysis. Kaplan-Meier assessment revealed an adverse outcome in subjects with procalcitonin above the median. Procalcitonin was related to markers of LV dysfunction and remodelling.
Conclusion: Procalcitonin is associated with MACE, LV dysfunction and remodelling post-AMI.

• 出版日期2010-6