A Case of Lambert-Eaton Myasthenic Syndrome with Small-Cell Lung Cancer and Transient Increase in Anti-Acetylcholine-Receptor-Binding Antibody Titer

作者：Lee Jung Hwan; Shin Ha Young; Kim Seung Min; Sunwoo Il Nam^*

来源：Journal of Clinical Neurology, 2012, 8(4): 305-307.

DOI：10.3988/jcn.2012.8.4.305

• Lambert-Eaton myasthenic syndrome
• small-cell lung carcinoma
• myasthenia gravis

Background Lambert-Eaton myasthenic syndrome (LEMS) is a presynaptic neuromuscular junction disorder that is most frequently associated with small-cell lung cancer (SCLC). The titers of antibodies against voltage-gated calcium channels are frequently increased in LEMS, but only rarely is titer of anti-acetylcholine-receptor-binding antibodies (AChR-abs) increased. Case Report A 57-year-old male was admitted to our hospital due to dry mouth and eyes and progressive proximal limb weakness of 2 months duration. The results of a repetitive nerve stimulation test disclosed all criteria for the electrophysiological LEMS pattern, and the patient's AChR-abs titer was 0.587 nmol/L. At a follow-up performed 5 years after successful treatment of SCLC and LEMS, his AChR-abs titer had decreased to 0.001 nmol/L. Conclusions We suggest that this was a case of transient pseudopositivity of AChR-abs in SCLC with LEMS. J Clin Neurol 2012;8:305-307

• 出版日期2012-12