Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

作者：Reaper Philip M^*; Griffiths Matthew R; Long Joanna M; Charrier Jean Damien; MacCormick Somhairle; Charlton Peter A; Golec Julian M C; Pollard John R

来源：Nature Chemical Biology, 2011, 7(7): 428-430.

DOI：10.1038/NCHEMBIO.573

Here we report a comprehensive biological characterization of a potent and selective small-molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound synthetic lethal interaction between ATR and the ATM-p53 tumor suppressor pathway in cells treated with DNA-damaging agents and establish ATR inhibition as a way to transform the outcome for patients with cancer treated with ionizing radiation or genotoxic drugs.

• 出版日期2011-7