Directing cell motions on micropatterned ratchets

作者：Mahmud Goher; Campbell Christopher J; Bishop Kyle J M; Komarova Yulia A; Chaga Oleg; Soh Siowling; Huda Sabil; Kandere Grzybowska Kristiana^*; Grzybowski Bartosz A

来源：Nature Physics, 2009, 5(8): 606-612.

DOI：10.1038/NPHYS1306

Cell motility is a process deriving from the synchronized dynamics of the cytoskeleton. In several important physiological processes-notably, cancer metastasis-the randomly moving cells can acquire a directional motility phenotype and bias their motions in response to environmental cues. Despite intense research, however, the current understanding of directional cell migration is incomplete and there is a growing need to develop systems that would enable the study and control of this process. This article demonstrates that random motions of motile cells can be rectified by asymmetric ('ratchet') microgeometries. Interactions between the cells and the imposed geometrical cues guide cell polarization and give rise to directional motility. Depending on the ratchet design, cells of different types can move either in the same or in opposite directions on the same imposed pattern. In the latter case, it is possible to partially sort mixed cell populations into different collecting reservoirs.

• 出版日期2009-8
• 单位西北大学