An Improved Protocol for the Synthesis of alpha-Trifluoromethylthio-Substituted Ketones by Copper-Mediated Trifluoromethylthiolation of alpha-Bromo Ketones

作者：Huang, Yangjie; He, Xing; Li, Haohong; Weng, Zhiqiang^*

来源：European Journal of Organic Chemistry, 2014, 2014(33): 7324-7328.

DOI：10.1002/ejoc.201403221

• Synthetic methods
• Trifluoromethylthiolation
• Copper
• Ketones
• Fluorine

An efficient and practical approach to -trifluoromethylthio-substituted ketones was developed. The trifluoromethylthiolation of (bpy)Cu(SCF3) (bpy = 2,2-bipyridyl) with various -bromo ketones afforded the desired -trifluoromethylthio-substituted ketones in good yields. The reaction tolerates more functionally than previously reported methods and demonstrates efficient scalability and practicality.

• 出版日期2014-11
• 单位福州大学