Facile synthesis of thiazoles via an intramolecular thia-Michael strategy

作者：Sasmal Pradip K^*; Sridhar S; Iqbal Javed

来源：Tetrahedron Letters, 2006, 47(49): 8661-8665.

DOI：10.1016/j.tetlet.2006.09.157

• thiazoles
• thia-Michael
• benzotriazoles
• desilylation

A mild and efficient method for the synthesis of substituted thiazoles is reported via one-pot N-desilylation, thioacylation/oxythioacylation/thiothioacylation followed by thia-Michael cycloisomerisation. This method has a general applicability to introduce various oxo and thio functionalities including aliphatic and aromatic moieties, especially at the C2-position of thiazoles.

• 出版日期2006-12-4