Antibody Against Tumor Necrosis Factor-alpha Reduces Bortezomib-induced Allodynia in a Rat Model

作者：Chiorazzi Alessia^*; Canta Annalisa; Meregalli Cristina; Carozzi Valentina; Sala Barbara; Oggioni Norberto; Monbaliu Johan; Van de Velde Helgi; Cavaletti Guido

来源：Anticancer Research, 2013, 33(12): 5453-5459.

• Bortezomib-induced neuropathy
• allodynia
• tumor necrosis factor-alpha
• anti-TNF alpha

Background: Bortezomib is an anti-neoplastic drug acting against multiple myeloma but its use is associated with the onset of painful peripheral neuropathy. Tumor necrosis factor-alpha (TNF alpha) is associated with the development of neuropathic pain; several models have shown that the inactivation of TNF alpha leads to a reduction in pain stimuli perception. The aim of the present study was to analyze if the administration of an antibody against TNF alpha is able to prevent the development of bortezomib-induced neuropathic pain. Materials and Methods: Nerve conduction velocity was measured and a histopathological examination was performed to assess the extent of peripheral neuropathy. To study the onset of painful neuropathy, the response to mechanical or thermal stimuli was evaluated. Results: This study demonstrated that co-administration of an antibody against TNF alpha is able to prevent allodynia induced by bortezomib but does not reduce neuropathy. Conclusion: Targeting TNF alpha might be useful in limiting patients%26apos; discomfort during bortezomib therapy.

• 出版日期2013-12