Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma

作者：Zhang, Bei; Han, Siqi; Feng, Bing; Chu, Xiaoyuan; Chen, Longbang; Wang, Rui^*

来源：Experimental and Molecular Medicine, 2017, 49(2): e293.

DOI：10.1038/emm.2016.177

• EPITHELIAL-MESENCHYMAL TRANSITION
• ABERRANT DNA METHYLATION
• TUMOR-SUPPRESSOR
• UP-REGULATION
• EPIGENETIC REPRESSION
• CELL-PROLIFERATION
• CANCER DEVELOPMENT
• DOWN-REGULATION
• LIVER-CANCER
• CYCLIN D1

Hepatitis B virus (HBV) has an important role in the development of human hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV-encoded X protein (HBx) can induce both genetic alterations in tumor suppressor genes and oncogenes, as well as epigenetic aberrations in HCC pathogens. Non-coding RNAs (ncRNAs) mainly include microRNAs and long non-coding RNAs (lncRNAs). Although ncRNAs cannot code proteins, growing evidence has shown that they have various important biological functions in cell proliferation, cell cycle control, anti-apoptosis, epithelial-mesenchymal transition, tumor invasion and metastasis. This review summarizes the current knowledge regarding the mechanisms and emerging roles of ncRNAs in the pathogenesis of HBV-related HCC. Accumulated data have shown that ncRNAs regulated by HBx have a crucial role in HBV-associated hepatocarcinogenesis. The findings of these studies will contribute to more clinical applications of HBV-related ncRNAs as potential diagnostic markers or as molecular therapeutic targets to prevent and treat HBV-related HCC.

• 出版日期2017-2
• 单位南京医科大学