Addition of unactivated thiols to epoxides and oxetanes catalyzed by a rhenium-oxo complex

作者：Badiceanu Alexandra D; Garst Alyson E; Trubitt Meredith E; Nolin Kristine A^*

来源：Catalysis Communications, 2014, 47: 67-70.

DOI：10.1016/j.catcom.2014.01.005

• Rhenium catalysis
• Epoxides
• Oxetanes
• Regioselective
• Thiols

A method for synthesizing beta- and gamma-hydroxy thioethers via addition of unactivated thiols to epoxides and oxetanes has been developed. This reaction is proposed to proceed through an unconventional mode of activation of the heterocycles. The transformation is catalyzed by ReO2I(PPh3)(2) affording beta- and gamma-hydroxy thioethers in moderate to excellent yield with excellent regioselectivity.

• 出版日期2014-3-5