Mannose metabolism: More than meets the eye

作者:Sharma Vandana*; Ichikawa Mie; Freeze Hudson H
来源:Biochemical and Biophysical Research Communications, 2014, 453(2): 220-228.
DOI:10.1016/j.bbrc.2014.06.021

摘要

Mannose is a simple sugar with a complex life. It is a welcome therapy for genetic and acquired human diseases, but it kills honeybees and blinds baby mice. It could cause diabetic complications. Mannose chemistry, metabolism, and metabolomics in cells, tissues and mammals can help explain these multiple systemic effects. Mannose has good, bad or ugly outcomes depending on its steady state levels and metabolic flux. This review describes the role of mannose at cellular level and its impact on organisms.

  • 出版日期2014-10-17