Natural variation in Caenorhabditis briggsae mitochondrial form and function suggests a novel model of organelle dynamics

作者：Hicks Kiley A; Denver Dee R; Estes Suzanne^*

来源：Mitochondrion, 2013, 13(1): 44-51.

DOI：10.1016/j.mito.2012.12.006

• Complex I
• Electron transport chain
• Membrane potential
• Mitochondrial dynamics
• nad5 Delta
• Reactive oxygen species

Mitochondrial functioning and morphology are known to be connected through cycles of organelle fusion and fission that depend upon the mitochondrial membrane potential (Delta Psi M); however, we lack an understanding of the features and dynamics of natural mitochondrial populations. Using data from our recent study of univariate mitochondrial phenotypic variation in Caenorhabditis briggsae nematodes, we analyzed patterns of phenotypic correlation for 24 mitochondrial traits. Our findings support a role for Delta Psi M in shaping mitochondrial dynamics, but no role for mitochondrial ROS. Further, our study suggests a novel model of mitochondrial population dynamics dependent upon cellular environmental context and with implications for mitochondrial genome integrity.

• 出版日期2013-1