Usefulness of cytologic criteria in ultrasound-guided fine-needle aspirates from subcentimeter canine mammary tumors

作者：Pierini Alessio^*; Millanta Francesca; Zanforlin Roberta; Vannozzi Iacopo; Marchetti Veronica

来源：Journal of Veterinary Diagnostic Investigation, 2017, 29(6): 869-873.

DOI：10.1177/1040638717718886

• Cytology
• dogs
• fine-needle aspiration
• mammary tumors
• nuclear morphometry

We determined cytologic features of histologically confirmed subcentimeter canine mammary tumors (CMTs) to determine reasonable criteria for an accurate cytologic diagnosis. Fifty-three CMTs from 28 bitches were included. All cytologic samples were collected by ultrasound-guided fine-needle aspiration biopsy, stained with May-Grunwald/Giemsa, and retrospectively evaluated using a scoring system established for 18 cytologic features. Mean nuclear area (MNA) was also measured for each sample by a computer-assisted program. Based on the histologic diagnosis, CMTs were divided into 2 groups: malignant tumors (25) and benign lesions (15). Data were statistically analyzed using Fisher and Mann-Whitney tests. Chromatin pattern (p < 0.05) and macrophage infiltration (p < 0.05) were significantly different between the groups. Median MNA was significantly (p < 0.05) larger in malignant tumors. The evaluation of these cytologic features in subcentimeter CMTs may increase the sensitivity of cytology.

• 出版日期2017-11