Elucidation on enhanced application of synthesised kojic acid immobilised magnetic and chitosan tri-polyphosphate nanoparticles as antibacterial agents

作者：Chaudhary Jignesh^*; Lakhawat Sudarshan; Pathak Amrendra Nath

来源：IET Nanobiotechnology, 2015, 9(6): 375-380.

DOI：10.1049/iet-nbt.2014.0077

• nanoparticles
• nanomedicine
• Fourier transform infrared spectra
• antibacterial activity
• magnetic materials
• synthesised kojic acid immobilised magnetic nanoparticles
• chitosan tri-polyphosphate nanoparticles
• anti-bacterial agents
• aspergillus species
• secondary metabolite
• multi-functional skeleton
• biotechnology
• chitosan tri-polyphosphate
• Fourier transformation infrared spectroscopy
• amino propyl triethoxy silane-coated MNPs
• chitosan-TPP nanoparticles
• Gram positive
• Staphylococcus aureus

Kojic acid (KA) is a secondary metabolite which is secreted by several aspergillus species. It is a multi-functional skeleton from which many derivatives can be synthesised and applied in various areas of biotechnology. KA grafting on synthesised magnetic nanoparticles (MNPs) and chitosan tri-polyphosphate (chitosan-TPP) nanoparticles was successfully done and characterised by Fourier transformation infrared spectroscopy. It was observed that amino propyl triethoxy silane-coated MNPs and chitosan-TPP nanoparticles enhanced the antibacterial activity of KA against both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa). The organic constitution and significant antibacterial activity of KA-chitosan-TPP nanoparticles can be applicable in the field of medical biotechnology.

• 出版日期2015-12