Neonatal Outcomes in Twin Pregnancies Delivered Moderately Preterm, Late Preterm, and Term

作者：Refuerzo Jerrie S^*; Momirova Valerija; Peaceman Alan M; Sciscione Anthony; Rouse Dwight J; Caritis Steve N; Spong Catherine Y; Varner Michael W; Malone Fergal D; Iams Jay D; Mercer Brian M; Thorp John M Jr; Sorokin Yoram; Carpenter Marshall W; Lo Julie; Harper Margaret

来源：American Journal of Perinatology, 2010, 27(7): 537-542.

DOI：10.1055/s-0030-1248940

• Twin pregnancy
• late preterm birth
• neonatal morbidities

We compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB), and term birth. A secondary analysis of a multicenter, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 32(0)/(7) and 33(6)/(7) weeks and LPTB between 34(0)/(7) and 36(6)/(7) weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonary dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, LPTB 49 8%, and term birth rate 35.7%. The rate of the primary outcome was different between groups: 30.0% for MPTB, 12.8% for LPTB, 0.5% for term birth (p < 0.001). Compared with term neonates, the primary neonatal outcome composite was increased following MPTB (relative risk [RR] 58.5; 95% confidence interval [CI] 11 3 to 1693.0) and LPTB (RR 24.9, 95% CI 4.8 to 732.2). Twin pregnancies born moderately and late preterm encounter higher rates of neonatal morbidities compared with twins born at term

• 出版日期2010-8
• 单位西北大学