Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp FKI-3389

作者：Mori Mihoko; Morimoto Hiromi; Kim Yong Pil; Ui Hideaki; Nonaka Kenichi; Masuma Rokuro; Sakamoto Kimitoshi; Kita Kiyoshi; Tomoda Hiroshi; Shiomi Kazuro^*; Omura Satoshi

来源：Tetrahedron, 2011, 67(35): 6582-6586.

DOI：10.1016/j.tet.2011.05.090

• Electron transport enzyme inhibitor
• NADH-fumarate reductase
• Penicillium
• Ukulactone

Screening for NADH-fumarate reductase inhibitors led to the isolation of the new polyketide compounds, ukulactones A and B (1 and 2, Fig. 1) from a culture broth of Penicillium sp. FKI-3389. The structure of ukulactone A was elucidated as a methylated derivative of prugosene A1, which was produced by Penicillium rugulosum and NOESY experiment revealed ukulactone B was a stereoisomer of ukulactone A. Ukulactone A showed potent inhibitory activity against NADH-fumarate reductase of the roundworm Ascaris suum in vitro.

• 出版日期2011-9-2