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Demchenko IT, Mahon RT, Allen BW, Piantadosi CA. Brain oxygenation and CNS oxygen toxicity after infusion of perfluorocarbon emulsion. J Appl Physiol 113: 224-231, 2012. First published May 3, 2012; doi: 10.1152/japplphysiol.00308.2012.-Intravenous perfluorocarbon (PFC) emulsions, administered with supplemental inspired O-2, are being evaluated for their ability to eliminate N-2 from blood and tissue prior to submarine escape, but these agents can increase the incidence of central nervous system (CNS) O-2 toxicity, perhaps by enhancing O-2 delivery to the brain. To assess this, we infused a PFC emulsion (Oxycyte, 6 ml/kg iv) into anesthetized rats and measured cerebral PO2 and regional cerebral blood flow (rCBF) in cortex, hippocampus, hypothalamus, and striatum with 100% O-2 at 1, 3, or 5 atmospheres absolute (ATA). At 1 ATA, brain PO2 stabilized at >20 mmHg higher in animals infused with PFC emulsion than in control animals infused with saline, and rCBF fell by similar to 10%. At 3 ATA, PFC emulsion raised brain PO2 >70 mmHg above control levels, and rCBF decreased by as much as 25%. At 5 ATA, brain PO2 was >= 159 mmHg above levels in control animals for the first 40 min but then rose sharply; rCBF showed a similar profile, reflecting vasoconstriction followed by hyperemia. Conscious rats were also pretreated with PFC emulsion at 3 or 6 ml/kg iv and exposed to 100% O-2 at 5 ATA. At the lower dose, 80% of the animals experienced seizures by 33 min compared with 50% of the control animals. At the higher dose, seizures occurred in all rats within 25 min. At these doses, administration of PFC emulsion poses a clear risk of CNS O-2 toxicity in conscious rats exposed to hyperbaric O-2 at 5 ATA.
- 出版日期2012-7
