Development of Sm-153-bleomycin as a possible therapeutic complex

作者：Bahrami Samani Ali; Ghannadi Maragheh Mohammad; Jalilian Amir Reza^*; Yousefnia Hassan; Moradkhani Sedigheh; Bolourinovin Fatemeh

来源：Nuclear Science and Techniques, 2010, 21(3): 165-170.

• Bleomycin
• Sm-153
• Biodistribution
• Radiolabeling

Due to interesting therapeutic properties of Sm-153 and antineoplastic antibiotic, bleomycin (BLM), Sm-153-bleomycin (Sm-153-BLM) was developed as a possible therapeutic compound using (SmCl3)-Sm-153 and BLM. The (SmCl3)-Sm-153 was obtained by thermal neutron flux (5 x 10(13) n.cm(-2).s(-1)) of an enriched (Sm2O3)-Sm-152 sample, dissolved in acidic media. Under optimized conditions (room temperature, 45 min, 0.1 mg bleomycin for 740-3700 MBq (SmCl3)-Sm-153) a radiochemical purity over 98 % was obtained shown by HPLC (Specific activity = 55 Thq/mM). The (SmCl3)-Sm-153 and Sm-153-BLM were administered into wild-type rats up to 96 h followed by biodistribution. The SPECT imaging of labeled compound in wild-type rats was performed and significant image pattern was observed for a radiolabeled bleomycin compound. The (153)Sin-BLM is a potential therapeutic compound and our experiments on this compound have shown satisfactory quality, and stability suitable for future therapeutic studies.

• 出版日期2010-6-20