Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in rice field eel (Monopterus albus) after a single-dose intramuscular or oral administration

作者：Xie, L. -L.; Wu, Z. -X.^*; Chen, X. -X.; Li, Q.; Yuan, J.; Liu, H.; Yang, Y.

来源：Journal of Veterinary Pharmacology and Therapeutics, 2013, 36(3): 229-235.

DOI：10.1111/j.1365-2885.2012.01413.x

• SALMON SALMO-SALAR
• ATLANTIC
• CHLORAMPHENICOL
• OXYTETRACYCLINE
• THIAMPHENICOL
• EFFICACY
• DELIVERY

The pharmacokinetics of florfenicol (FF) and its metabolite, florfenicol amine (FFA), were studied in rice field eel (Monopterus albus) after a single dose (20mg/kg) by intramuscular (i.m.) or oral gavage (p.o.) dose at 25 degrees C. The elimination half-lives (t1/2), peak concentration of FF (Cmax), and time to reach FF peak concentration (Tmax) in plasma were estimated as 18.39h, 10.83g/mL, and 7.00h, respectively, after i.m. injection and 13.46h, 8.37g/mL, and 5h, respectively, after p.o. administration. The Tmax values of FF in tissues (i.e., kidney, muscle, and liver) were larger for i.m. injection compared with those for p.o. administration. The t1/2 had the following order kidney>muscle>liver for i.m. administrated and kidney>liver>muscle for p.o. administrated. The largest area under the concentrationtime curve (AUC) was calculated to be 384.29mg center dot h/kg after i.m. dosing, and the mean residence time (MRT) was 42.46h by oral administration in kidney. FFA was also found in all tissues with a lower concentration than FF for both i.m. and p.o. administrations throughout the study. The elimination of FFA was slow with a t1/2 between 18.19 and 47.80h in plasma and tissues. The mean metabolic rate of FFA for i.m. and p.o. administrations was >23.30%.

• 出版日期2013-6
• 单位华中农业大学