Body Weight Difference Between Donor and Recipient Is an Important Affector of Early Graft Function After Renal Transplantation

作者：Ge, F.; Gong, W.^*

来源：Transplantation Proceedings, 2013, 45(6): 2171-2175.

DOI：10.1016/j.transproceed.2012.12.003

• KIDNEY WEIGHT
• ALLOGRAFT FUNCTION
• IN-VIVO
• RATIO
• MODEL
• MASS
• CREATININE
• REJECTION
• IMPACT
• TH2

Background. Poor early graft EGF), a frequent complication of kidney transplantation, can be caused by many risk factors, including donor kidney and body weights. @@@ Methods. We studied the relationship to early graft function in a rat kidney transplantation model among 3 indices: ratio of graft to body weight; ratio of native kidney to body weight, and weight difference/body weight of the recipient. We categorized 2 groups based on contralateral nephrectomy at day 1 (G1) or day 3 (G2) after transplantation. EGF was evaluated by measuring serum creatinine levels at day 1 after bilateral nephrectomy. @@@ Results. The 3 indices, ie, weight difference/body weight of recipient (G1 and G2: P < .0001), ratio of native kidney to body weight (G1: P < .0001; G2: P = .0013), and ratio of graft to body weight (G1: P = .0064; G2: P = .014) strongly correlated with EGF regardless of the time of contralateral nephrectomy. @@@ Conclusions. The index of weight difference/body weight of recipient sensitively and predominantly influenced EGF, which probably reflects the systemic metabolic profile.

• 出版日期2013-7
• 单位浙江大学