The association of breast disease and atypical glandular cells on cervical cytology

作者：Schnatz Peter F^*; Pattison Kristine; O'Sullivan David M

来源：Menopause-The Journal of the North American Menopause Society, 2011, 18(1): 67-72.

DOI：10.1097/gme.0b013e3181e32742

• Atypical glandular cells
• Breast disease and cancer
• Cervical disease
• Dysplasia
• Malignancy
• Colposcopy
• Papanicolaou testing

Objective: This study seeks to determine whether an association exists between atypical glandular cells (AGC) on cervical cytology and breast disease.
Methods: We analyzed 470,147 Papanicolaou test results from January 1, 2002, to November 17, 2008, inclusive. We studied all cases of AGC versus a control group with normal Papanicolaou test results. The database was then searched to determine which of these women had a history of breast disease. A comparison of the prevalence of breast disease between the two groups was performed.
Results: Of the 470,147 total Papanicolaou tests, 1,087 cases of AGC (0.23%) were identified from 1,026 women. There were 1,064 women comprising the normal population. The mean +/- SD age of these two groups was 44.9 +/- 13.7 and 41.6 +/- 14.4 years, respectively. Among the women with an AGC on Papanicolaou testing, 40 (3.9%) had breast disease compared with 21 (2.0%) among those without an AGC on Papanicolaou testing (P = 0.009). Among the 40 women with an AGC on their Papanicolaou test and breast disease, 7 (17.5%) also had a concerning gynecologic (Gyn) pathologic finding at the level of the cervix, endocervix, or uterus. In comparison, the women with normal Papanicolaou test results had no Gyn pathologic findings.
Conclusions: The prevalence of an abnormal Gyn pathologic finding in those with AGC is consistent with prior data. Women from this data set who have an AGC on Papanicolaou testing have a statistically higher likelihood of having concurrent breast disease. Further data are needed to elucidate the reason for this association.

• 出版日期2011-1