Muscle-Specific Receptor Tyrosine Kinase (MuSK) Myasthenia Gravis

作者：Hurst Rebecca L^*; Gooch Clifton L

来源：Current Neurology and Neuroscience Reports, 2016, 16(7): 61.

DOI：10.1007/s11910-016-0668-z

• Myasthenia gravis
• Muscle-specific receptor tyrosine kinase
• Acetylcholine receptor antibody
• Neuromuscular junction

Autoimmune myasthenia gravis (MG) is the prototypic, antibody-mediated neuromuscular disease and is characterized by a decrease in the number of functional acetylcholine receptors (AChR) within the muscle end plate zone of the neuromuscular junction (NMJ). Although the pathophysiology of AChR-mediated myasthenia gravis has been extensively studied over the last 40 years since its original description by Patrick and Lindstrom(Science 180: 871-872, 1973), less is known about the much more recently described muscle-specific kinase (MuSK) antibody-mediated MG. MuSK-MG has features clinically distinct from Ach-R MG, as well as a different pattern of response to treatment and a unique immunopathogenesis.

• 出版日期2016-7