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摘要
An unprecedented 6 pi-electrocyclization-aromatization cascade reaction of ynedienamines is described. The electron-rich ynedienamine is converted by gamma-protonation to an electrophilic allenyl iminium species which is susceptible to amine addition generating a highly electron-rich triene intermediate. The 6 pi-electrocyclization is accelerated by three electron-donating substituents in a captodative manner. Subsequent redox-neutral aromatization allows the direct synthesis of 1,3-diaminobenzenes from readily available ynedienamines.
- 出版日期2017-4-17
- 单位北京大学深圳研究生院; 中国工程物理研究院
