Direct observation of a transient polymorph during crystallization

作者:Hughes Colan E; Harris Kenneth D M*
来源:Chemical Communications, 2010, 46(27): 4982-4984.
DOI:10.1039/c0cc01007c

摘要

Application of a technique developed for in situ solid-state (13)C NMR studies of crystallization processes reveals direct evidence that crystallization of glycine from a methanol/water solution involves the initial transient formation of the beta polymorph, which then undergoes a solution-mediated polymorphic transformation to yield the more stable alpha polymorph.

  • 出版日期2010