High visfatin expression predicts poor prognosis of upper tract urothelial carcinoma patients

作者：Ke, Hung-Lung; Lin, Hui-Hui; Li, Wei-Ming; Li, Ching-Chia; Chang, Lin-Li; Lee, Yi-Chen; Huang, Chun-Nung; Wu, Wen-Jeng^*

来源：American Journal of Cancer Research, 2015, 5(8): 2447-2454.

• Nampt/PBEF/visfatin
• upper tract urothelial carcinoma
• immunohistochemistry
• prognosis
• survival

Visfatin, a newly discovered adipocytokine, is a pro-inflammatory cytokine. This study aimed to evaluate the predictive value of visfatin on prognosis of patients with upper tract urothelial carcinoma. One-hundred and five patients (median age=64, range=24-84 years) were included in this study. Visfatin expression in upper tract urothelial carcinoma tissues was analyzed by immunohistochemistry. Visfatin expression was correlated with clinicopathologic variables using the chi(2) test. The prognostic value of visfatin for recurrence-free and cancer-specific survival was evaluated by Kaplan-Meier estimates, and the significance of differences between curves was evaluated by the log-rank test. Cox regression model was also used to evaluate the hazard ratios of visfatin on survival. High visfatin expression in upper tract urothelial carcinoma tissues was significantly correlated with tumor stage (P=0.001), grade (P=0.007) and p53 expression (P=0.07). High visfatin expression was associated with poor recurrence-free and cancer-specific survival. Cox regression analysis also revealed that visfatin is an independent predictor of recurrence-free (HR=3.22, P=0.009) and cancer-specific survival (HR=5.74, P=0.023). Our findings indicated that higher visfatin expression is a potential biomarker to predict patient survival. Further study is necessary to investigate the role of visfatin in the carcinogenesis of upper tract urothelial carcinoma.

• 出版日期2015
• 单位河北医科大学