MANAGEMENT OF SPINAL METASTASES FROM RENAL CELL CARCINOMA USING STEREOTACTIC BODY RADIOTHERAPY

作者：Nguyen Quynh Nhu; Shiu Almon S; Rhines Laurence D; Wang He; Allen Pamela K; Wang Xin Shelley; Chang Eric L^*

来源：International Journal of Radiation Oncology, Biology, Physics, 2010, 76(4): 1185-1192.

DOI：10.1016/j.ijrobp.2009.03.062

• Metastatic renal cell carcinoma
• Stereotactic hotly radiosurgery
• Spinal SBRT

Purpose: To evaluate the outcomes associated with stereotactic body radiotherapy (SBRT) in the management of spinal metastases from renal cell carcinoma (RCC).
Methods and Materials: SBRT was used in the treatment of patients with spinal metastases from RCC. Patients received either 24 Gy in a single fraction, 27 Gy in three fractions, or 30 Gy delivered in five fractions. Effectiveness of SBRT with respect to tumor control and palliation of pain was assessed using patient-reported outcomes.
Results: A total of 48 patients with 55 spinal metastases were treated with SBRT with a median follow-up time of 13.1 months (range, 3.3-54.5 months). The actuarial 1-year spine tumor progression free survival was 82.1%. At pretreatment baseline, 23% patients were pain free; at 1 month and 12 months post-SBRT, 44% and 52% patients were pain free, respectively. No Grade 3-4 neurologic toxicity was observed.
Conclusions: The data support SBRT as a safe and effective treatment modality that can be used to achieve good tumor control and palliation of pain associated with RCC spinal metastases. Further evaluation with randomized trials comparing SBRT to conventional radiotherapy may be warranted.

• 出版日期2010-3-15