Aberrant expression of NK cell receptors in Epstein-Barr virus-positive gamma delta T-cell lymphoproliferative disorders

作者：Zhang Yu; Ohyashiki Junko H^*; Shimizu Norio; Ohyashiki Kazuma

来源：Hematology, 2010, 15(1): 43-47.

DOI：10.1179/102453310X12583347009450

• Lymphoproliferative disorder
• gamma-delta T-cell
• nature killer cell associated receptor

To clarify the difference between gene expression signature of Epstein-Barr virus (EBV)-positive gamma delta T-cell lymphoproliferative disorders (LPD) and those in normal gamma delta T-cells, we set out to determine gene expression profiling using three gamma delta T-cell lines derived from patients with EBV-positive gamma delta T-cell LPD. Gene expression profiling using an Affymetrix Genechip revealed a unique gene expression pattern of NK cell receptors in gamma delta T-LPD cell lines. Genes encoding killer cell lectin-like receptors (KLR), such as KLRG1 and KLRB1 (CD161), were generally low in gamma delta T-LPD cell lines, while killer cell immunoglobulin-like receptors varied among cell lines. In addition, expression of CD161 surface antigen was found to be remarkably decreased in gamma delta T-LPD cell lines by flow cytometric analysis. We conclude that gamma delta T-cell expansion in EBV-positive gamma delta T-LPD is in part due to inappropriate expression of the NK cell receptors which related to impaired function cytotoxic T cells.

• 出版日期2010-2