Are CRH & NGF as psychoneuroimmune regulators in women with polycystic ovary syndrome?

作者：Zangeneh F Z^*; Naghizadeh M M; Bagheri M; Jafarabadi M

来源：Gynecological Endocrinology, 2017, 33(3): 227-233.

DOI：10.1080/09513590.2016.1250152

• CRH
• interleukins
• NGF
• polycystic ovary syndrome
• tumor necrosis factor alpha
• sympathetic nervous system

Purpose: Polycystic ovary syndrome (PCOS) affects quality of life and can worsen anxiety and depression either due to the features of PCOS or due to the diagnosis of a chronic disease. Corticotrophin-releasing hormone (CRH) and nerves growth factor (NGF) are the modulator for the actions of the sympathetic nervous and immune systems.
Methods: In total, 171 women divided into two groups: study and control groups. Serum CRH, NGF, and interleukins: IL-1. IL-1, 17A, and TNF were determined by ELISA Kits in both groups.
Results: The results showed that IL-1 (p<0.001) and (p=0.017) significantly increased in PCO group. CRH, NGF, and IL-17 in serum of patients with PCO significantly lower than the control group (p<0.001). The results of this study indicate: (1) destruction of three cytokines pattern, (2) Reduction of CRH, NGF, and IL-17 in serum of PCO patients can be under the direct influence of the sympathetic nervous system (SAS), and (3) reduction of CRH and NGF can be reason of psych/emotional distress in women with PCOS.
Conclusions: The results of this study confirm (1) low-grade chronic inflammation in PCOS. This impaired cytokine pattern can play a major role in the immune-pathogenesis of PCOS; (2) hyponeurotrophinemia and reduction of CRH in women with PCOS could reFLect deficit of neuronal stress-adaptation in these patients.

• 出版日期2017-3