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摘要
Background and Objectives: This study looked at the frequency and differences in presentation, laboratory parameters, and outcome between ascitic acute viral hepatitis (AAVH) and nonascitic acute viral hepatitis (NAVH) in children.
Methods: Diagnosis of AVH was based on clinical features, > 3-fold elevation of alanine aminotransferase, viral marker positivity (IgM antihepatitis A virus, IgM antihepatitis E virus, hepatitis B surface antigen, and IgM antihepatitis B core antigen) at presentation, absence of history of liver disease, and subsequent normalization within 6 months of clinical features and liver functions including sustained resolution of ascites in AAVH on follow-up.
Results: A total of 139 children (121 children with NAVH and 18 with AAVH, 12.9%) were studied. Children with AAVH in comparison with those with NAVH were younger (median age 4 vs 8 years), had lower frequency of prodrome (22% vs 51%), lower serum albumin (median 2.8 vs 3.7 g/dL), low total serum protein (median 6.5 vs 7.4 g/dL), and prolongation of prothrombin time (median 4.8 vs 1.05 seconds); all P < 0.03. No significant differences were found in sex, height standard deviation scores, duration of symptoms, liver span or consistency, transaminases, alkaline phosphatase, and etiology of NAVH versus AAVH. Among the AAVH group clinically detectable ascites was present in 38.9% (7/18), spontaneous bacterial peritonitis in 11%, and diuretics had to be used ill 44% of cases. Ascites resolved in all of the cases in 8 weeks (94.4% cases in < 4 weeks) and liver functions normalized in 17%, 50%, and 33% cases in < 4, 4 to 8, and > 8 weeks duration, respectively.
Conclusions: We report AAVH as a distinct entity that affects younger children., This subgroup has compromised biosynthetic liver functions irrespective of viral etiology with total recovery.
- 出版日期2010-2
- 单位河北医科大学
