Association of the MAPT locus with Parkinson's disease

作者：Wider C^*; Vilarino Guell C; Jasinska Myga B; Heckman M G; Soto Ortolaza A I; Cobb S A; Aasly J O; Gibson J M; Lynch T; Uitti R J; Wszolek Z K; Farrer M J; Ross O A

来源：European Journal of Neurology, 2010, 17(3): 483-486.

DOI：10.1111/j.1468-1331.2009.02847.x

• association studies
• genetics
• MAPT
• Parkinson's disease

Background and purpose:
Whilst an association between the tau gene (MAPT)-containing H1 haplotype and supranuclear gaze palsy (PSP) has long been recognized, the effect of H1 on risk for Parkinson's disease (PD) has remained more contentious.
Methods:
Herein, we examined the association of H1 and PD in three Caucasian PD patient-control series from Ireland, Norway, and the US (combined: n = 2619), by genotyping two H1/H2 single nucleotide polymorphisms (SNPs) in MAPT (rs1052553) and in the Saitohin gene (rs62063857) and one H1-specific SNP (rs242557).
Results:
We identified a significant association between H1/H2 and risk of PD (rs1052553 OR: 1.43, CI: 1.23-1.64; rs62063857 OR: 1.45, CI: 1.27-1.67), but no effect of the H1-specific SNP rs242557 (OR: 0.92, CI: 0.82-1.03).
Conclusions:
Our findings show that the H1 haplotype is a significant risk factor for PD. However, one H1-specific SNP (rs242557) previously implicated in PSP did not alter the risk of PD, indicating that distinct H1 sub-haplotypes probably drive the associations with PD and PSP.

• 出版日期2010-3