Antibacterial activity and increased osteoblast cell functions of zinc calcium phosphate chemical conversion on titanium

作者：Guo, Yong-Yuan; Liu, Bing; Hu, Bei-Bei; Xiao, Gui-Yong; Wu, Yun-Peng; Sun, Peng-Fei; Zhang, Xian-Long; Jia, Yu-Hua^*; Lu, Yu-Peng^*

来源：Surface and Coatings Technology, 2016, 294: 131-138.

DOI：10.1016/j.surfcoat.2016.03.085

• Antibacterial
• Zn
• Titanium
• Osteoblast
• Osteogenesis

To enhance the osteointegration and antibacterial property of titanium (Ti) implant, zinc calcium phosphate chemical conversion (Zn-Ca-PCC) was fabricated on pure Ti by phosphate chemical conversion technique. The surface of the coating was verified by combined techniques of scanning electron microscopy, energy-dispersive X-ray spectrometry, atomic force microscopy and water contact angle measurements. Plate-like Zn-Ca-PCC coatings are built up on the surface of Ti. The results obtained from the antibacterial studies suggest that the Zn-Ca-PCC coatings can greatly inhibit the growth of both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria. Moreover, the in vitro evaluations demonstrate that the adhesion, proliferation and differentiation of osteoblasts on Zn-Ca-PCC coatings were significantly enhanced compared with pure Ti. In conclusion, innovative Zn-Ca-PCC coatings on Ti with excellent antibacterial activity and biocompatibility are promising candidates for orthopedic and dental implants.

• 出版日期2016-5-25
• 单位上海交通大学; 山东大学