科研之友
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摘要
Evaluation of: Hall CB, Caserta MT, Schnabel K et al.: Chromosomal integration of human herpesvirus 6 is the major mode of congenital human herpesvirus 6 infection. Pediatrics 122(3), 513-520 (2005). Human herpesvirus (HHV)-6 is the cause of exanthem subitum, a common childhood illness. In common with the other human HHVs, it establishes lifelong latency with occasional reactivation, but unlike the other members of its family, it has an alternative form of persistence, specifically, integration of viral sequences into host chromosomes characterized by very high HHV-6 DNA loads in blood. This phenomenon was first discovered in the early 1990s but, until recently, was considered extremely rare. However, accumulating evidence suggests that chromosomal integration is uncommon rather than rare and that its usual mode of transmission is in the germline. The present article confirms this possibility; it is the culmination of an ongoing prospective survey of congenital HHV-6 infection that will no doubt shed further light on the, as of yet, unknown clinical consequences of the fascinating phenomenon of chromosomally integrated HHV-6.
- 出版日期2009-5
- 单位河北医科大学
