A DMAP-catalyzed mild and efficient synthesis of 1,2-dihydroquinazolines via a one-pot three-component protocol

作者：Derabli Chamseddine; Boulcina Raouf^*; Kirsch Gilbert; Carboni Bertrand; Debache Abdelmadjid

来源：Tetrahedron Letters, 2014, 55(1): 200-204.

DOI：10.1016/j.tetlet.2013.10.157

• Multicomponent reaction
• 1,2-Dihydroquinazolines
• DMAP
• 2-Aminobenzophenone

An efficient and simple method for the synthesis of 1,2-dihydroquinazolines catalyzed by 4-(N,N-dimethylamino)pyridine (DMAP) from readily available aromatic or heteroaromatic aldehydes, 2-aminobenzophenone, and ammonium acetate under mild conditions is described. The scope and limitations of the method are discussed.

• 出版日期2014-1-1