Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro

作者：Chiou Chun Tang; Kuo Yao Haur; Chan Yu Yi; Juang Shin Hun; Chan Hsiu Hui; Wu Tian Shung^*

来源：Phytochemistry, 2012, 80: 64-69.

DOI：10.1016/j.phytochem.2012.05.005

• Ajuga taiwanensis
• Labiatae
• Ajugalide-B
• ATMA
• Anoikis
• Anti-cancer

Ajuga taiwanensis is widely used for the treatment of hepatitis and hepatoma in Taiwanese folk medicine. However, its bioactive components and mechanism of action are unclear. Herein, ajugalide-B (ATMA), a neoclerodane diterpenoid isolated from Ajuga taiwanensis, is reported to exhibit high anti-proliferative activity against tumor cell lines from various tissues. These results demonstrate that ATMA disrupts the focal adhesion complex by decreasing phosphorylation of paxillin and focal adhesion kinase (FAK). As a result, anoikis, a specific type of apoptosis caused by detachment of cells, is triggered by activation of caspase-8 in A549 cells. Furthermore, ATMA also blocks anchorage-independent growth and cell migration and, therefore, ATMA may serve as a lead compound for the developing of anti-cancer therapeuties with anoikis-inducing properties.

• 出版日期2012-8
• 单位中国医科大学