Anti-Heat Shock Protein 27 Titers and Oxidative Stress Levels are Elevated in Patients With Valvular Heart Disease

作者：Rahsepar Amir Ali; Mirzaee Asadollah; Moodi Fatemeh; Moohebati Mohsen; Tavallaie Shima; Eshraghi Ali; Alavi Maryam Sadat; Zarrabi Laya; Pourghadamyari Hossein; Paydar Roghayeh; Khojasteh Roshanak; Mousavi Somayeh; Kia Nadia; Amini Maral; Ghayour Mobarhan Majid^*; Ferns Gordon A A

来源：Angiology, 2012, 63(8): 609-616.

DOI：10.1177/0003319711433308

• heat shock protein
• antibody
• pro-oxidant-antioxidant balance
• valvular heart disease

We studied the immune responses to heat shock protein (Hsp)-27 and pro-oxidant-antioxidant balance (PAB) values in patients with valvular heart disease, but free of angiographically evident coronary artery disease (CAD). Patients who were candidates for valvuloplasty surgery and 30 healthy matched controls were recruited. The anti-Hsp-27 antibody titers were 0.35 +/- 0.04 absorbency units (AU) in the valvuloplasty group, being significantly higher than for the controls (0.11 +/- 0.02 AU; P < .05). The PAB values were significantly higher in cases (134.67 +/- 13.69 Hamidi-Koliakos(HK) unit) when compared with controls (49.78 +/- 6.75 HK unit; P < .05). In cases, the ejection fraction was inversely correlated with anti-Hsp-27 antibody (P < .05) but was not significantly related to PAB values (P > .05). Based on the echocardiographic findings, the patients had no evident heart failure, but the high levels of anti-Hsp-27 and PAB values in patients with valvular heart disease may indicate that these variables can be used as markers of heart failure. However, a longitudinal study is required to confirm this hypothesis.

• 出版日期2012-11