Aortoventricular annulus shape as a predictor of pacemaker implantation following transcatheter aortic valve replacement

作者：Barkagan Michael; Topilsky Yan; Steinvil Arie; Aviram Galit; Ben Shoshan Jeremy; Finkelstein Ariel; Banai Shmuel; Keren Gad; Shmilovich Haim^*

来源：Journal of Cardiovascular Medicine, 2017, 18(6): 425-429.

DOI：10.2459/JCM.0000000000000497

• aortoventricular annulus
• conduction system
• pacemaker
• transcatheter aortic valve replacement

Aims Conduction abnormalities following transcatheter aortic valve replacement (TAVR) are caused by damage of the aortoventricular conduction tissue during positioning of the valve. Therefore, our aim was to assess whether a higher difference between the long and short diameters of the elliptic aortoventricular annulus will possess higher forces on the annulus, and thus will be a predictor of pacemaker need following TAVR.
Methods We retrospectively analyzed 123 patients who had the aortoventricular annulus measured by computed tomography angiography. The difference between maximal (D-max) and minimal (D-min) diameters of the annulus was considered the elliptic factor (ELFA), which was analyzed using t test to evaluate whether it differs between the group who received a pacemaker and the group without the need for a pacemaker. Then, using univariate and multivariate models adjusted for other confounders predicting the need for a pacemaker, we sought to evaluate whether a higher ELFA is a predictor of pacemaker implantation.
Results Mean age was 82.2 +/- 6.4 years, and 62.6% were women. Average D-max, D-min and ELFA were 25.8, 20.8 and 5mm, respectively. Fourteen patients (11.4%) underwent pacemaker implantation. Those patients had an ELFA of 5.9mm compared with 4.9mm in those who did not receive a pacemaker (P<0.01). In multivariate analysis, a higher ELFA remained a statistically significant and independent predictor for the need of a pacemaker (P = 0.046).
Conclusion A high ELFA is an independent and significant predictor of the need for pacemaker implantation after TAVR and suggests further investigation whether it should be considered as a factor in managing TAVR patients.

• 出版日期2017-6