A possible prevention strategy of radiation pneumonitis: Combine radiotherapy with aerosol inhalation of hydrogen-rich solution

作者：Chuai Yunhai; Zhao Luqian; Ni Jin; Sun Ding; Cui Jianguo; Li Bailong; Qian Liren; Gao Fu; Cai Jianming^*

来源：Medical Science Monitor, 2011, 17(4): HY1-HY4.

• radiotherapy
• pneumonitis
• hydrogen
• radioprotection

Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, we hypothesize that a treatment combining radiotherapy with aerosol inhalation of a hydrogen-rich solution may be an effective and novel prevention strategy for radiation pneumonitis (hydrogen is explosive, while a hydrogen-rich solution such as physiological saline saturated with molecular hydrogen is safer).

• 出版日期2011-4
• 单位中国人民解放军第二军医大学