Antimycobacterial and antileishmanial effects of microfungi isolated from tropical regions in Mexico

作者：Gamboa Angulo Marcela^*; Molina Salinas Gloria M; Chan Bacab Manuel; Peraza Sanchez Sergio R; Heredia Gabriela; de la Rosa Garcia Susana C; Reyes Estebanez Manuela

来源：Parasitology Research, 2013, 112(2): 559-566.

DOI：10.1007/s00436-012-3167-4

A total of 82 fungal extracts were selected and screened against Mycobacterium tuberculosis and promastigotes of Leishmania mexicana strains. Results showed inhibitory activity in 29 % of the fungal strains against at least one of the targets tested. The most significant antituberculosis (antiTB) effects were presented by Cylindrocarpon sp. XH9B, Fusarium sp. TA54, Fusarium XH1Ga, Gliocladium penicillioides TH04 and TH21, Gliocladium sp. TH16, Kutilakesa sp. MR46, and Verticillium sp. TH28 strains (minimal inhibition concentration (MIC) = 1.56-25 mu g/ml). Mortality of L. mexicana promastigotes was displayed by only four strains, Fusarium sp. TA50, Fusarium sp. TA54, Verticillium sp. TH28, and the unidentified 2TA2 strain (IC50 = 14.23-100 mu g/ml and IC100 = 50-100 mu g/ml). Seven of these most active strains were defatted and their corresponding fractions evaluated again. The results showed the best antiTB activity in Gliocladium sp. TH16 (MIC = 1.56 mu g/ml) and the highest leishmanicidal potential in Fusarium sp. TA54 (IC50 = 6.36 mu g/ml). These results show that fungi living in the tropical regions of M,xico have the ability to produce bioactive metabolites that could be used in the near future as natural products to control neglected tropical diseases.

• 出版日期2013-2