Accessing the amide functionality by the mild and low-cost oxidation of imine

作者：Mohamed Magdi A; Yamada Ken ichi; Tomioka Kiyoshi^*

来源：Tetrahedron Letters, 2009, 50(26): 3436-3438.

DOI：10.1016/j.tetlet.2009.02.174

Oxidation of imines using sodium chlorite under buffered conditions gave the corresponding amides in good to high yield. The reaction was generally fast and was completed within 5-40 min. As has been established in the corresponding oxidation of aldehyde, so-called Pinnick oxidation, the good functional group tolerance and the use of inexpensive reagents are the advantages of this protocol.

• 出版日期2009-7-1