Do Intraoperative Hemodynamic Factors of the Recipient Influence Renal Graft Function?

作者：Campos L^*; Parada B; Furriel F; Castelo D; Moreira P; Mota A

来源：Transplantation Proceedings, 2012, 44(6): 1800-1803.

DOI：10.1016/j.transproceed.2012.05.042

Purpose. To assess the importance of intraoperative management of recipient hemodynamics for immediate versus delayed graft function. %26lt;br%26gt;Methods. The retrospective study of 1966 consecutive renal transplants performed in our department between June 1980 and December 2009 analyzed several perioperative hemodynamic factors: central venous pressure (CVP), mean arterial pressure (MAP) as well as volumes of fluids, fresh frozen plasma (FFP), albumin, and whole blood transfusions. We examined their influence on renal graft function parameters: immediate diuresis, serum creatinine levels, acute rejection, chronic transplant dysfunction, and graft survival. %26lt;br%26gt;Results. Mean CVP was 9.23 +/- 2.65 mm Hg and its variations showed no impact on graft function. We verified a twofold greater risk of chronic allograft dysfunction among patients with CVP %26gt;= 11 mm Hg (P %26lt; .001). Mean MAP was 93.74 +/- 13.6 mm Hg; graft survivals among subjects with MAP %26gt;= 93 mm Hg were greater than those of patients with MAP %26lt; 93 mm Hg (P = .04). On average, 2303.6 +/- 957.4 mL of saline solutions were infused during surgery. Patients who received whole blood transfusions (48%) showed a greater incidence of acute rejection episodes (ARE) (P = .049) and chronic graft dysP %26lt; .001). Patients who received FFP (55.7%), showed a higher incidence of ARE (P %26lt; .001). Only 4.6% of patients (n = 91) received human albumin with a lower incidence of ARE (P = .045) and chronic graft dysP = .024). Logistic binary regression analysis revealed that plasma administration was an independent risk factor for ARE (P %26lt; .001) and chronic dysP = .028). Volume administration ( %26gt;= 2500 mL) was also an independent risk factor for chronic allograft dysP = .016). Using Cox regression, we verified volume administration %26gt;= 2500 mL to be the only independent risk factor for graft failure (P %26lt; .001). %26lt;br%26gt;Conclusion. MAP %26gt;= 93 mm Hg and perioperative fluid administration %26lt; 2500 mL were associated with greater graft survival. Albumin infusion seemed to be a protective factor, while CVP %26gt;= 11 mm Hg, whole blood, and FFP transfusions were associated with higher rates of ARE and chronic graft dysfunction.

• 出版日期2012-8