An Impaired Awareness of Hypoglycemia Improved After Vitamin B-12 Treatment in a Type 1 Diabetic Patient

作者：Fujita Shingo; Kozawa Junji; Ishibashi Chisaki; Kimura Takekazu; Kitamura Tetsuhiro; Fukui Kenji; Yasuda Tetsuyuki; Iwahashi Hiromi; Imagawa Akihisa; Shimomura Iichiro

来源：Internal Medicine, 2017, 56(11): 1383-1385.

DOI：10.2169/internalmedicine.56.8489

• impaired awareness of hypoglycemia
• vitamin B-12
• type 1 diabetes
• central nervous system
• counter-regulatory hormone

An impaired awareness of hypoglycemia is a serious problem in diabetic patients, which can lead to life-threatening severe hypoglycemia. Recurrent hypoglycemia attenuates the function of the central, mainly hypothalamic, nervous system and it causes an impaired awareness of hypoglycemia. Vitamin B-12 deficiency is also associated with the dysfunction of central nervous system. We report a 72-year-old type 1 diabetic patient with vitamin B-12 deficiency whose impaired awareness of hypoglycemia improved after 4 weeks of vitamin B-12 administration with an increased counter-hormone secretion in response to hypoglycemia. We should recognize vitamin B-12 deficiency as one of the causes of an impaired awareness of hypoglycemia in diabetic patients.

• 出版日期2017