An efficient synthesis and antimicrobial activity of 3-benzylidene-1-phenylquinoline-2,4(1H,3H)-diones

作者：Jadhav S A; Sangshetti J N; Pardeshi R K^*; Shinde D B

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2017, 56(3): 341-347.

• Anti-bacterial activity
• anti-fungal activity
• N-phenylquinolone
• TCT
• TEA
• water

Cyanuric chloride has been reported for the first time for the synthesis of N-phenylhydroxyquinolone in TCM as solvent Further, it is condensed with various aromatic aldehydes in water with triethylamine as base The yields obtained are in the range of 82-97% under the microwave method All the synthesized compounds (Q1-Q10) belong to a new series and have been evaluated for their antibacterial and antifungal activity Synthesised series of quinolones, compounds Q2, Q3, Q5, Q8 and Q9 show activity against E coli, P aeruginosa, S aureus and B subtilis All synthesised compounds are found to be more potent than the standard drugs Ciprofloxacin and Miconazole when tested against the fungal strains C albicans and A niger.

• 出版日期2017-3