Disulfide-stabilized Fv fragments (dsFv): a new type of engineering antibody fragments.

作者：Mao CS; Song HB; Wang HT

来源：Progress in Biochemistry and Biophysics, 1998, 25(6): 522-526.

• disulfide-stabilized Fv fragment
• engineering
• molecular design

Disulfied-stabilized Fv (dsFv) fragments are new type of engineering antibody, in which varible regions ol heavy chain (VK) and light chain (V-L) are stabilized by an interchain disulfide bond. dsFv is more stable, an important biochemical feature for the preparation and handling of these proteins in clinical setting.

• 出版日期1998-12
• 单位中国人民解放军军事医学科学院