Age-Related Macular Degeneration (AMD): Alzheimer's Disease in the Eye?

作者：Kaarniranta Kai^*; Salminen Antero; Haapasalo Annakaisa; Soininen Hilkka; Hiltunen Mikko

来源：Journal of Alzheimer's Disease, 2011, 24(4): 615-631.

DOI：10.3233/JAD-2011-101908

• Age-related macular degeneration (AMD)
• aggregation
• aging
• Alzheimer's disease
• autophagy
• lysosome
• oxidative stress
• proteasome

Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease that shares several clinical and pathological features with Alzheimer's disease (AD), including stress stimuli such as oxidative stress and inflammation. In both diseases, the detrimental intra- and extracellular deposits have many similarities. Aging, hypercholesterolaemia, hypertension, obesity, arteriosclerosis, and smoking are risk factors to develop AMD and AD. Cellular aging processes have similar organelle and signaling association in the retina and brain tissues. However, it seems that these diseases have a different genetic background. In this review, differences and similarities of AMD and AD are thoroughly discussed.

• 出版日期2011