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摘要
Objective: To discuss the therapeutic effects of autologous platelet-rich gel (APG) in the treatment of limbs refractory wound infection. Methods: A total of sixty patients with refractory wound infection in lower limb weretreated in our hospital from January 2016 to December 2016, who had received one month of wound treatment but unhealed. After random grouping, thirty of them were treated with APG as the treatment group (Group APG), the rest thirty were treated with isotonic saline as the control group (Group Con). The wound areas, pain scores and colony-forming units (CFU) on infected tissue of the patients in the two groups on admission and those at the 7th day after treatment, the complications on the 7th day after therapy and thr follow-up cure time of patients were compared and analyzed. Results: The wound areas in Group APG at the 7th day after therapy were evidently declined compared with those on admission (P=0.021). At the same time, the wound areas of Group APG were smaller than those of Group Con (P=0.035). The wound CFU of two groups were both decreased gradually from the 1st to the 7th day after treatment (all P<0.05). Besides, the decline in Group APG was sharper than in Group Con (P=0.003). There was no statistical difference in patients' wound pain scores in two groups. The cure time of Group APG was 15.2 +/- 2.2 days, while that of Group Con was 20.2 +/- 2.2 days, and the differencehad statistical significance (P=0.032). The wound infection rate (P<0.001) and scar index (P=0.049) of Group APG after treatment were apparently lower than those of Group Con. Conclusion: Autologous platelet-rich gel can decrease wound areas, reduce CFU on wound, shorten the wound cure time and lessen the occurrence of complications.
- 出版日期2017
- 单位河南大学
