Regions, systems, and the brain: Hierarchical measures of functional integration in fMRI

作者：Marrelec Guillaume^*; Bellec Pierre; Krainik Alexandre; Duffau Hugues; Pelegrini Isaac Melanie; Lehericy Stephane; Benali Habib; Doyon Julien

来源：Medical Image Analysis, 2008, 12(4): 484-496.

DOI：10.1016/j.media.2008.02.002

• fMRI
• functional brain interactions
• functional connectivity
• integration
• mutual information
• information proper
• multiinformation
• low-grade glioma
• brain plasticity
• surgery

In neuroscience, the notion has emerged that the brain abides by two principles: segregation and integration. Segregation into functionally specialized systems and integration of information flow across systems are basic principles that are thought to shape the functional architecture of the brain. A measure called integration, originating from information theory and derived from mutual information, has been proposed to characterize the global integrative state of a network. In this paper, we show that integration can be applied in a hierarchical fashion to quantify functional interactions between compound systems, each system being composed of several regions. We apply this method to fMRI datasets from patients with low-grade glioma and show how it can efficiently extract information related to both intra- and interhemispheric reorganization induced by lesional brain plasticity.

• 出版日期2008-8