Diet Supplementation with Allicin Protects against Alcoholic Fatty Liver Disease in Mice by Improving Anti-inflammation and Antioxidative Functions

作者：Panyod Suraphan; Wu Wei Kai; Ho Chi Tang; Lu Kuan Hung; Liu Chun Ting; Chu Yung Lin; Lai Yi Syuan; Chen Wei Cheng; Lin Yu En; Lin Shih Hang; Sheen Lee Yan^*

来源：Journal of Agricultural and Food Chemistry, 2016, 64(38): 7104-7113.

DOI：10.1021/acs.jafc.6b02763

• alcoholic fatty liver disease
• liver inflammation
• allicin
• liver antioxidant
• hepatic steatosis

This study investigated the liver-protective effects of allicin, an active compound in fresh garlic, against alcoholic fatty liver disease (AFLD) and liver inflammation. Its effects were investigated in an AFLD model in male C57BL/6 mice, which were fed Lieber-DeCarli liquid diet containing ethanol. Allicin (5 and 20 mg/kg bw/day) was orally administered daily in the AFLD mice for 4 weeks. The results indicate that allicin promotes hepatoprotection by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels (p < 0.05) in the plasma, which are key indicators of liver damage. Allicin reduced fat accumulation, increased glutathione and catalase levels, and decreased microsomal protein cytochrome P450 2E1 (CYP2E1) expression (p < 0.05) in the livers of the AFLD mice. Furthermore, Akin supplementation significantly decreased the levels of proinflammatory tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, and IL-6 and suppressed the expression of sterol regulatory element-binding protein-1 (SREBP-1) (p < 0.05). Additionally, it improved the hepatic alcohol dehydrogenase (ADH) activity (p < 0.05). Collectively, these findings demonstrate that allicin attenuates liver oxidative stress and inflammation.

• 出版日期2016-9-28