Attenuation of respiratory immune responses by antiviral neuraminidase inhibitor treatment and boost of mucosal immunoglobulin A response by co-administration of immuno-modulator clarithromycin in paediatric influenza

作者：Kido Hiroshi^*; Takahashi Etsuhisa; Kataoka Kosuke; Fujii Kazuyuki; Suzuki Satoshi; Iwase Kazuhiro; Ito Chika

来源：Influenza and Other Respiratory Viruses, 2011, 5: 240-243.

• Oseltamivir
• mucosal immunity
• immune modulator
• macrolide antibiotic clarithromycin

Oseltamivir (OSV) is widely used to suppress viral replication in the treatment of influenza. Here, we report that OSV administration significantly suppressed respiratory mucosal secretory IgA (sIgA) responses, but not systemic IgG responses, in weanling mice as a model of pediatric influenza. Treatment with clarithromycin (CAM), a macrolide with immunomodulatory activities, in pediatric influenza boosted the production of sIgA against influenza A virus (IAV) in nasal washes (NWs) and alleviated the respiratory disease manifestations, particularly in patients treated with OSV. Our findings suggest that CAM boosts mucosal anti-viral sIgA responses and prevents the risk of re-infection in the OSV-treated patients.

• 出版日期2011-5