Application of Capmul MCM and caprylic acid for the development of danazol-loaded SEDDS

作者：Li Suhua; Madan Parshotam; Lin Senshang^*

来源：Pharmaceutical Development and Technology, 2015, 20(7): 886-896.

DOI：10.3109/10837450.2014.943408

• Capmul MCM:CA (1:1)
• danazol
• dispersion/precipitation
• SEDDS
• solubilization capacity

The feasibility of using Capmul MCM and caprylic acid (medium-chain triglyceride pre-digestion products) as the lipid phase was investigated for the development of self-emulsifying drug delivery system (SEDDS) as a carrier system to enhance solubilization of poorly water-soluble danazol. The composition of SEDDS was first evaluated by phase diagrams of lipid/surfactant/water systems. Thereafter, danazol-loaded SEDDS was formulated and subjected to dispersion/ precipitation study in distilled water, HCl buffer, phosphate buffer, or biorelevant aqueous media. The mechanism of danazol dispersion was investigated by comparing the solubilization capacity of blank SEDDS dispersed in various aqueous media with respective dispersion/precipitation profiles obtained. Phase diagrams showed that at least 30% (w/w) Cremophor RH40, as the surfactant, was needed to properly emulsify Capmul MCM: caprylic acid (1:1), as the lipid phase. Different extent of danazol precipitation was observed upon the dispersion of danazol-loaded SEDDS in different aqueous media. Danazol precipitation was dominated by the solubilization capacity of danazol, which was influenced by the ratio of Capmul MCM: CA and Cremophor RH40, pH of aqueous media, gastrointestinal composition, and blank SEDDS concentration.

• 出版日期2015