Unravelling Spinal Circuits of Pain and Mechanical Allodynia

作者:Gangadharan Vijayan; Kuner Rohini
来源:Neuron, 2015, 87(4): 673-675.
DOI:10.1016/j.neuron.2015.08.013

摘要

How do spinal circuits mediating tactile sensation and pain get entangled to evoke allodynia, i.e., pain sensation, in response to a normally innocuous stimulus? Recent breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons and their polysynaptic connectivity to calretinin-expressing neurons are now identified as key determinants of the spinal circuitry underlying mechanical allodynia.

  • 出版日期2015-8-19